1-methyl-4-phenylpyridinium

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Definition of 1-methyl-4-phenylpyridinium in English English dictionary

MPP+, the active metabolite of MPTP

Apical uptake was higher than basolateral uptake at 37 degrees C and was decreased to 70% in the presence of NaN(3) or in the absence of extracellular Na(+). Besides alpha2-agonists, apical uptake was inhibited by verapamil, desipramine, and quinidine, but not by MPP(+) (1-methyl-4-phenylpyridinium), TEA (tetraethylammonium), decynium-22, carnitine, PHA (p-aminohippurate), alanine, or inosine.

A neurotoxin which cannot cross the blood brain barrier, but once in contact it can destroy the dopaminergic neurons of the substantia nigra