O, yorgun olduğu gerçeğine rağmen çalışmaya devam etti.
- In spite of the fact that he was tired, he continued working.
Tom çok parası olması gerçeğine rağmen iyi bir adam.
- Tom is a nice guy in spite of the fact that he has a lot of money.
... the cold hard fact is that ...
... the second fact is that the population is going to grow more slowly depending… the ...