O, yorgun olduğu gerçeğine rağmen çalışmaya devam etti.
 - In spite of the fact that he was tired, he continued working.
Tom çok parası olması gerçeğine rağmen iyi bir adam.
 - Tom is a nice guy in spite of the fact that he has a lot of money.
... the cold hard fact is that ...
... fact is that if you are lowering the rates the way you describe, Governor, then it is ...