prometaphase

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Definition of prometaphase in English English dictionary

The stage between prophase and metaphase in mitosis

(Biyoloji) Prometaphase is the phase of mitosis following prophase and preceding metaphase, in eukaryotic somatic cells. The nuclear envelope breaks into fragments and disappears. Microtubles emerging from the centrosomes at the poles (ends) of the spindle reach the chromosomes, now highly condensed. At the centromere region, each sister chromatid has a protein structure called a kinetochore. Some of the spindle microtubles attach to the kinetochores, throwing the chromosomes into agitated motion. Other spindle microtubules make contact with microtubules coming from opposite pole. Forces exerted protein "motors" associated with spindle microtubules move the chromosomes toward the center of the cell