Definition of proband in English English dictionary
An individual who presents with a genetic disorder or other specific characteristic, when this leads to the investigation of the individual's family
The original individual, who because of their specific characteristic (e g extreme longevity) causes a study of other family members to determine if they have the same characteristic and if they have hereditary or genetic factors in common that could explain such a coincidence
An individual who presents with a genetic disorder, and whose family is then investigated
– The person whose case serves as the stimulus for the study of other members of the family to identify the possible genetic factors involved in a given disease, condition, or characteristic