If you describe someone as estranged from something such as society or their profession, you mean that they no longer seem involved in it. Arran became increasingly estranged from the mainstream of Hollywood
If you are estranged from your family or friends, you have quarrelled with them and are not communicating with them. Joanna, 30, spent most of her twenties virtually estranged from her father
arouse hostility or indifference in where there had formerly been love, affection, or friendliness remove from customary environment or associations; "Her busy schedule removed her from her duties as a mother
[ is-'trAnj ] (transitive verb.) 15th century. Middle English, from Middle French estranger, from Medieval Latin extraneare, from Latin extraneus strange; more at STRANGE.