Cholestasis is a non-specific term for a build up of bile in the liver This can happen for many different reasons At times the cholestasis is related to a transient injury of the liver and it will often go away on its own It can also be caused by drugs, in which case it may go away if the drug is discontinued Cholestasis can also be the result of liver diseases such as sclerosing cholangitis, biliary atresia, primary biliary cirrhosis, and others