a chemical produced by cells that stimulates the activity of other cells Certain chemokines are associated with autoimmune disorders, and some (e g , MIP-1-alpha, MIP-1-beta, RANTES) have been shown to affect the activity of HIV
a soluble factor secreted by certain immune system cells that stimulates the activity of other cells Chemokines have chemoattractant properties and act as messengers between cells Alpha chemokines contain an amino acid between 2 cysteine residues; beta chemokines do not contain an intervening amino acid Certain chemokines (e g , MIP-1-alpha, MIP-1-beta, RANTES) have been shown to affect the activity of HIV; certain chemokine receptors (e g , CCR-5, CXCR-4) are necessary for entry by HIV into cells
Soluble chemical messengers that attract white blood cells to the site of infection There are two structural categories of chemokines: alpha (CXC) and beta (CC)