Biyokimyada bir ligand (Latince ligare = bağlanmak) bir biyomoleküle bağlanarak bir kompleks oluşturan bir bileşiktir. Genelde, iyonik bağlar, hidrojen bağları veya Van der Waals güçleri ile hedef bir proteindeki bağlanma yerine bağlanır. Ligand molekülün bağlanma yerine yanaşması genelde tersinir, yani birleşme ve ayrışma arasında bir denge vardır. Biyolojik sistemlerde bir ligandın hedef molekülü ile tersinmez kovalent bağlanması enderdir. İnorganik kimyadaki ligand tanımından farklı olarak, (hemoglobinde olduğu gibi) ligandın mutlaka bir metale bağlanması şart değildir. Sinyal reseptörlerine bir ligand bağlanınca reseptör proteinin üç boyutlu şekli değişebilir, bu da onun işlevsel özelliğini değiştirir. Bağlanma eğilimi veya gücüne "afinite" denir. Ligand tipleri arasında substratlar, inhibitörler, aktivatörler, ve nörotrasnmitterler sayılabilir. Radyoligandlar, radyoizotopla işaretlenmiş bileşiklerdir, ligand bağlanma ölçümlerinde kullanılırlar,
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Biyokimyada bir ligand (Latince ligare = bağlanmak) bir biyomoleküle bağlanarak bir kompleks oluşturan bir bileşiktir. Genelde, iyonik bağlar, hidrojen bağları veya Van der Waals güçleri ile hedef bir proteindeki bağlanma yerine bağlanır. Ligand molekülün bağlanma yerine yanaşması genelde tersinir, yani birleşme ve ayrışma arasında bir denge vardır. Biyolojik sistemlerde bir ligandın hedef molekülü ile tersinmez kovalent bağlanması enderdir. İnorganik kimyadaki ligand tanımından farklı olarak, (hemoglobinde olduğu gibi) ligandın mutlaka bir metale bağlanması şart değildir. Sinyal reseptörlerine bir ligand bağlanınca reseptör proteinin üç boyutlu şekli değişebilir, bu da onun işlevsel özelliğini değiştirir. Bağlanma eğilimi veya gücüne "afinite" denir. Ligand tipleri arasında substratlar, inhibitörler, aktivatörler, ve nörotrasnmitterler sayılabilir. Radyoligandlar, radyoizotopla işaretlenmiş bileşiklerdir, ligand bağlanma ölçümlerinde kullanılırlar
An ion, molecule, or functional group that binds to another chemical entity to form a larger complex, A Lewis base that can coordinate to a metal atom, (Chemistry) An ion or molecule attached to a metal atom by coordinate bonding, (Biochemistry) A molecule that selectively binds to another, A Lewis base in a coordination compound, = Date: 1949: noun: a group, ion, or molecule coordinated to a central atom or molecule in a complex, A chemical which binds to a receptor, A molecule that reacts to form a complex with another molecule, A Lewis base coordinated with a metal atom or ion to form a coordination complex, Molecule, ion, or group bound to the central atom in a chelate or a coordination compound, an atom or molecule or radical or ion that forms a complex around a central atom, an ion or neutral molecule attached to the central metal ion in a coordination compound, A ligand is a substance which is capable of binding specifically and reversibly with a binder A ligand is termed an antigen when the binder is an antibody, Any chemical that binds to a receptor Ligands may be agonists or antagonists, The binding agent used in affinity chromatography A ligand is bound to a column of a nonadsorbent material and selectively binds a substance in solution, isolating it from impurities Commonly used ligands include enzymes (for binding to inhibitors) or antibodies (for binding to antigens), a molecule or ion that binds to a metal atom or ion through coordination of its lone electron pairs A coordination complex is formed when a metal ion is surrounded by a group of ligands, A ligand is any chemical which binds to, forms a chemical link with, some larger molecule or receptor On cells the binding is to the outer part of the cell surface If a ligand can bind to two sites at once, it is called a divalent ligand, if three, trivalent, and if many sites can be attacked at once polyvalent, A small molecule that binds to a receptor/protein, = molecule which binds to a receptor to form a complex, a molecule that binds to a specific receptor, A molecule that binds to a receptor protein, Atom, group (see functional group), or molecule attached to a central atom, usually of a transition element, in a coordination or complex compound (see bonding). It is almost always the electron-pair donor (nucleophile) in a covalent bond. Common ligands include the neutral molecules water (H2O), ammonia (NH3), and carbon monoxide (CO) and the anions cyanide (CN^-), chloride (Cl^-), and hydroxide (OH^-). Rarely, ligands are cations and electron-pair acceptors (electrophiles). Organic ligands include EDTA (see chelate) and nitrilotriacetic acid. Biological systems rely on ligands such as the porphyrin in hemoglobin and chlorophyll, and numerous cofactors are ligands. In chelates, the ligand attaches at more than one point, sharing more than one electron pair, and is called bidentate or polydentate having two or many "teeth." The ligands in a complex may be the same or different, any molecule that binds to another, A small molecule that binds to another larger molecule, Any molecule that binds to the surface of another molecule, such as an immune cell receptor For examples of receptors see CCR5, CXCR-4, CD4, In °protein chemistry, a small molecule that is (or can be) bound by a larger molecule is termed a ligand In organometallic chemistry, a moiety bonded to a central metal atom is also termed a ligand; the latter definition is more common in general chemistry, A molecule that can bind to a receptor and thereby induce a signal in the cell, e g , a hormone, Molecule that binds to a specific site on a protein or another molecule, A molecule which binds to a receptor molecule, producing a response (closing an ion channel, transmitting a signal inside the cell etc ), The ion or molecule which surrounds or complexes with the central atom or ion,
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An ion, molecule, or functional group that binds to another chemical entity to form a larger complex
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A Lewis base that can coordinate to a metal atom
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(Chemistry) An ion or molecule attached to a metal atom by coordinate bonding
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(Biochemistry) A molecule that selectively binds to another
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A Lewis base in a coordination compound
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= Date: 1949: noun: a group, ion, or molecule coordinated to a central atom or molecule in a complex
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A chemical which binds to a receptor
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A molecule that reacts to form a complex with another molecule
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A Lewis base coordinated with a metal atom or ion to form a coordination complex
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Molecule, ion, or group bound to the central atom in a chelate or a coordination compound
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an atom or molecule or radical or ion that forms a complex around a central atom
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an ion or neutral molecule attached to the central metal ion in a coordination compound
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A ligand is a substance which is capable of binding specifically and reversibly with a binder A ligand is termed an antigen when the binder is an antibody
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Any chemical that binds to a receptor Ligands may be agonists or antagonists
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The binding agent used in affinity chromatography A ligand is bound to a column of a nonadsorbent material and selectively binds a substance in solution, isolating it from impurities Commonly used ligands include enzymes (for binding to inhibitors) or antibodies (for binding to antigens)
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a molecule or ion that binds to a metal atom or ion through coordination of its lone electron pairs A coordination complex is formed when a metal ion is surrounded by a group of ligands
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A ligand is any chemical which binds to, forms a chemical link with, some larger molecule or receptor On cells the binding is to the outer part of the cell surface If a ligand can bind to two sites at once, it is called a divalent ligand, if three, trivalent, and if many sites can be attacked at once polyvalent
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A small molecule that binds to a receptor/protein
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= molecule which binds to a receptor to form a complex
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a molecule that binds to a specific receptor
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A molecule that binds to a receptor protein
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Atom, group (see functional group), or molecule attached to a central atom, usually of a transition element, in a coordination or complex compound (see bonding). It is almost always the electron-pair donor (nucleophile) in a covalent bond. Common ligands include the neutral molecules water (H2O), ammonia (NH3), and carbon monoxide (CO) and the anions cyanide (CN^-), chloride (Cl^-), and hydroxide (OH^-). Rarely, ligands are cations and electron-pair acceptors (electrophiles). Organic ligands include EDTA (see chelate) and nitrilotriacetic acid. Biological systems rely on ligands such as the porphyrin in hemoglobin and chlorophyll, and numerous cofactors are ligands. In chelates, the ligand attaches at more than one point, sharing more than one electron pair, and is called bidentate or polydentate having two or many "teeth." The ligands in a complex may be the same or different
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any molecule that binds to another
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A small molecule that binds to another larger molecule
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Any molecule that binds to the surface of another molecule, such as an immune cell receptor For examples of receptors see CCR5, CXCR-4, CD4
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In °protein chemistry, a small molecule that is (or can be) bound by a larger molecule is termed a ligand In organometallic chemistry, a moiety bonded to a central metal atom is also termed a ligand; the latter definition is more common in general chemistry
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A molecule that can bind to a receptor and thereby induce a signal in the cell, e g , a hormone
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Molecule that binds to a specific site on a protein or another molecule
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A molecule which binds to a receptor molecule, producing a response (closing an ion channel, transmitting a signal inside the cell etc )
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The ion or molecule which surrounds or complexes with the central atom or ion
Some etymologies, pronunciations, function and usage date content for the English translation portion are from Merriam-Webster Online at www.Merriam-Webster.com. Thanks to Online Yunanca Dil Eğitimi for providing some parts of online greek dictionary. To contribute more resources please contact us. Visuals(images) are provided by Google Image Search API. Some parts of the dictionary is contributed by many users, thank you! The content on this site is for informational purposes only. Bu aramada ligand kelimesinin sözlük anlamı ve eşanlamı nedir, nasıl okunur hakkında bilgi verilmektedir. ligand kelimesinin etimolojik ve eşanlamları ile ilgili açıklamalar ve bilgiler eksiksiz ve hatasız olarak anılmamalıdır. Burada yer alan ligand kelimesi ile ilgili tüm açıklamalar bilgi amaçlıdır. Eksik ve hatalı çevirileri lütfen bildiriniz.
