Happy is the man who can endure the highest and lowest fortune. He who has endured such vicissitudes with equanimity has deprived misfortune of its power.
a change, especially a complete change, of condition or circumstances, as of fortune
{i} unpredictable changes (especially during the course of a lifetime); variability; hardship during a lifetime
mutability in life or nature (especially successive alternation from one condition to another)
a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
mutability in life or nature (especially successive alternation from one condition to another) a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research